Approximately 70% of all human genes are expressed in colorectal cancer, with just over 1% of having increased expression in colorectal cancer compared to other forms of cancer.  Some genes are oncogenes : they are overexpressed in colorectal cancer. For example, genes encoding the proteins KRAS , RAF , and PI3K , which normally stimulate the cell to divide in response to growth factors, can acquire mutations that result in over-activation of cell proliferation. The chronological order of mutations is sometimes important. If a previous APC mutation occurred, a primary KRAS mutation often progresses to cancer rather than a self-limiting hyperplastic or borderline lesion.  PTEN , a tumor suppressor, normally inhibits PI3K, but can sometimes become mutated and deactivated. 
Among the widely used steroids is Deca-Durabolin. For the past three decades, Deca Durabolin steroid has delivered great gains to people looking for muscle mass and has the ability to reduce joint pain and boost the body’s immune system. The most important benefit of Deca-Durabolin for both amateur athletes and bodybuilders is that it doesn’t have serious side effects since it doesn’t convert to estrogen like other compounds. As such, Deca-Durabolin does not have severe or higher degree side effects that other compounds might have.