However, the Anavar steroid was discontinued by Searle in 1989, due to the bad press brought on by bodybuilders abusing the drug. It was later reintroduced to the world market as Oxandrin in 1995, but it remains a controlled substance under US law. The current manufacturer of oxandrolone holds all the rights to their medicine, and that’s why it is very rare to find oxandrolone today. It’s still called Anavar by most people, and it’s very hard to buy. Even if you do find Anavar for sale, the law of supply and demand inevitably results in a rather exorbitant price for the steroid.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.
Approximately 70% of all human genes are expressed in colorectal cancer, with just over 1% of having increased expression in colorectal cancer compared to other forms of cancer.  Some genes are oncogenes : they are overexpressed in colorectal cancer. For example, genes encoding the proteins KRAS , RAF , and PI3K , which normally stimulate the cell to divide in response to growth factors, can acquire mutations that result in over-activation of cell proliferation. The chronological order of mutations is sometimes important. If a previous APC mutation occurred, a primary KRAS mutation often progresses to cancer rather than a self-limiting hyperplastic or borderline lesion.  PTEN , a tumor suppressor, normally inhibits PI3K, but can sometimes become mutated and deactivated.