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Roferon-A (interferon alfa-2a, recombinant) should be administered with caution to patients with cardiac disease or with any history of cardiac illness. Acute , self-limited toxicities (., fever , chills) frequently associated with Roferon-A (interferon alfa-2a, recombinant) administration may exacerbate preexisting cardiac conditions. Rarely, myocardial infarction has occurred in patients receiving Roferon-A (interferon alfa-2a, recombinant) . Cases of cardiomyopathy have been observed on rare occasions in patients treated with alpha interferons.

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