Metabolic/Endocrine: Decreased glucose tolerance (see PRECAUTIONS ), increased serum levels of low-density lipoproteins and decreased levels of high-density lipoproteins (see PRECAUTIONS , Laboratory Tests ), increased creatine and creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Reversible changes in liver function tests also occur, including increased Bromsulphalein (BSP) retention and increases in serum bilirubin , glutamic-oxaloacetic transaminase ( SGOT ), and alkaline phosphatase .
Hot melt extrusion is utilized in pharmaceutical solid oral dose processing to enable delivery of drugs with poor solubility and bioavailability. Hot melt extrusion has been shown to molecularly disperse poorly soluble drugs in a polymer carrier increasing dissolution rates and bioavailability. The process involves the application of heat, pressure and agitation to mix materials together and ‘extrude’ them through a die. Twin-screw high shear extruders blend materials and simultaneously break up extruded particles can then be blended and compressed into tablets or filled into capsules. 
Christ. Finasteride has impotence, loss of interest in sex, trouble having an orgasm, abnormal ejaculation listed as "common" side effects. And "Less serious" side effects also include impotence, loss of interest in sex, or trouble having an orgasm, which may persist after discontinuation. I thought this was rare. Why on earth are these side effects considered non-serious? Does the doctor consider impotence in himself as non-serious? This is really disheartening, that they can list this s**t as non-serious. Fvck off with "non-serious". It's the same with many anti-depressants.